1
In only two of the prospective trials bipolar patients were analyzed separately.
2
Longer treatment duration may be required but evidence from prospective trials are lacking.
3
The beneficial role of such combined therapy justifies further research, including prospective trials.
4
Included studies were randomized controlled trials, meta-analyses, prospective trials, and retrospective cohort studies.
5
To date, limited prospective trials exist from which evidence-based management can be developed.
6
This hypothesis will have to be tested in future prospective trials.
7
The role of immunotherapy should be further investigated in prospective trials.
8
However, future prospective trials with larger sample sizes are needed to confirm these findings.
9
Formal HRQoL assessments should be incorporated as primary end points in future prospective trials.
10
Large prospective trials are required to prove that it preserves the GVL effect fully.
11
Due to its rarity and indolent natural history, large-scale prospective trials have been lacking.
12
Controlled prospective trials are required to establish the value of rituximab in idiopathic NS.
13
Several prospective trials are ongoing worldwide with very promising results.
14
Randomized prospective trials are needed to determine the place of adjuvant versus delayed radiotherapy.
15
Such findings need to be confirmed by larger prospective trials.
16
We weighed evidence from both controlled and uncontrolled prospective trials.
