Body weight was measured by research personnel and by questionnaire.

Families, and research personnel are blinded to group assignment.

Design: Throughout the 4-year trial, research personnel approached eligible critically ill patients or their substitute decision makers for informed consent.

Similarly, screening patients at risk for AKI with these platforms to alert research personnel will lead to improve study subject recruitment.

Nasal and throat swabs collected by research personnel were tested for influenza by real-time reverse transcription-polymerase chain reaction (RT-PCR).

Outcome measures included direct observation by research personnel and completion by staff caregivers of the 14-item, short form of the Cohen-Mansfield Agitation Inventory (CMAI).

Patients were randomly assigned (1:1, stratified by study site) for Protocol 1 by on-site research personnel using an online electronic data capture system.