1
If it's half-hearted, the most resistant parasites will survive and start afresh.
2
Background: The emergence of resistant parasites to artemisinin poses a threat to malaria treatment.
3
Furthermore, it was not possible to select for heparin- resistant parasites.
4
Genotypic analysis revealed a single point mutation in the beta subunit in resistant parasites.
5
Stopping AP early may result in mono-prophylaxis with atovaquone and possibly select for atovaquone- resistant parasites.
6
It is as if there are different ethnic groups of artemisinin- resistant parasites inhabiting the same region.
7
Artemisinin- resistant parasites also exhibit decelerated progression through the first part of the asexual intraerythrocytic development cycle.
8
The development of resistant parasites by adaptation with increasing concentrations of DIM generates random mutations in LdTOP1LS.
9
Adherence to a 7-day quinine treatment schedule is likely to be poor and may increase the risk of selecting resistant parasites.
10
We have measured microsatellite diversity at 26 markers around the dhfr gene in pyrimethamine-sensitive and - resistant parasites collected in southeast Africa.
11
Background: Understanding pattern of antimalarials use at large scale helps ensuring appropriate use of treatments and preventing the spread of resistant parasites.
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Conclusions: Functional analysis of artemisinin resistance subpopulations illustrates the strong interplay between ubiquitination and cell division or differentiation in artemisinin resistant parasites.
13
Intriguingly, BTZ-based inhibitors retain activity against atovaquone resistant parasites, suggesting this chemical class may provide an alternative to atovaquone in combination therapy.
14
Such a tool will be valuable to malaria elimination programmes, and will also help to spot and contain the spread of drug- resistant parasites from Asia.
15
Scientists fear a repeat of the global malaria resurgence after drug- resistant parasites emerged in Southeast Asia from the 1950s to the 1970s.
