The serum marker with the best accuracy to discriminate PCM cases from controls was sTNF-R2.

Late PE had higher levels of sTNF-R1 and sTNF-R2 than early PE.

These results indicate that the sustained expression of TNF-R2 in AM by BLM exposure may sensitize these cells to TNF-a-mediated toxicity.

This induction of TNF-R2 by BLM was significant on d 1 and increased with greater exposure time.

In summary, our data suggest a critical regulatory role of TNF-R2 signaling for disease exacerbation in Th1-mediated chronic colitis.

The increase in K(Ca)2.2 channel expression after TNF-alpha treatment was shown to be dependent on TNF-R2 and NF-kappaB activation.