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1
Researchers may have discovered a cheap, plentiful supply of human
transplant
cells
for the treatment of brain damage after stroke or injury.
2
Poor retention of
transplanted
cells
is the critical bottleneck of heart regeneration.
3
They found fat built up around the
transplanted
cells
after four weeks.
4
The small study's main goal was assessing the safety of the
transplanted
cells
.
5
The
transplanted
cells
were marked by enhanced green fluorescent protein.
6
However, therapeutic efficacy may be limited by poor survival and retention of
transplanted
cells
.
7
Liver cells, for example, did best when the
transplanted
cells
were 28 embryonic days old.
8
These findings demonstrate that biomaterials may be designed to control bone development from
transplanted
cells
.
9
However, poor long-term engraftment and survival of
transplanted
cells
have largely precluded effective cell replacement.
10
Also, the newly-
transplanted
cells
were resistant to the virus.
11
The
transplanted
cells
differentiated into vascular and sinusoidal endothelial cells, and vascular smooth muscle cells.
12
Serial MR imaging showed the possible detection of
transplanted
cells
in the early period of transplantation.
13
Intravital confocal fluorescence imaging tracked the persistence of the
transplanted
cells
over 6-months in living animals.
14
However, the ability to track the fate and function of
transplanted
cells
with current technologies is limited.
15
These results suggest that this dual-modal imaging strategy is feasible for non-invasively monitoring
transplanted
cells
in vivo.
16
TPPU results in a significant increase in the retention of
transplanted
cells
compared with cell treatment alone.