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However, SFRP4 does not control glucose homeostasis and β-cell mass in mice.
2
The islet β-cell is unusual in that glucose lacks an extracellular receptor.
3
This effect was not associated with enhanced β-cell proliferation or mass.
4
Type 2 diabetes incidence increases with age, while β-cell replication declines.
5
This was paralleled by an increase in β-cell proliferation and mass.
1
However, its association with insulin resistance and betacell function remains controversial.
2
Hence, our results implicate both CTL and cytokines in betacell destruction.
3
Insulin resistance and betacell function were assessed with the homeostasis model.
4
ATT also extended islet viability in mice after streptozotocin-induced betacell toxicity.
5
Objective: Study the role of hyperglycemia-induced betacell loss on grafted islet destruction.
1
The pancreaticbetacell is the major source of circulating insulin in adult mammals.
2
Glucocorticoid doses, insulin sensitivity and pancreaticbetacell function were compared among these groups.
3
In males, insulin resistance progresses to a severe form of diabetes accompanied by pancreaticbetacell failure.
4
APX-115 significantly improved pancreaticbetacell function by decreased fasting blood glucose levels and increased insulin levels.
5
These female SLE patients with hyperglycemia were characterized by insulin resistance and reduced pancreaticbetacell function, and they were relatively young.