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One patient who underwent LT is waiting for ENU due to post-cryotherapy complication.
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Here we review progress in ENU mutagenesis screening, with an emphasis on creating mouse models for human disorders.
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Our results demonstrate that the expression of differentiation antigens in ENU-induced experimental neurinomas parallels the results reported for human neurinomas.
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ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects.
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We report on a battery of behavioral screening tests that successfully identified several neurobehavioral mutants among a large-scale ENU-mutagenized mouse population.