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Race differences in Zp were not explained by these measures of mechanical load.
2
The relationship of changes in the ZP and cortical granules to infertility and in vitro culture requires further investigation.
3
Conclusion: The observed changes in ZP biochemistry and cortical granule quantitation demonstrate that failed fertilization is frequently associated with spontaneous cytoplasmic, but not nuclear, activation.
4
Objective: To determine the extent of biochemical changes in the zona pellucida (ZP) and cortical granule release in eggs failing to fertilize in IVF.