Significats de apical constriction en anglès

Endogenous Xenopus shroom was found to be expressed in cells engaged in apical constriction.

Conclusions: These data demonstrate that Shroom is an essential regulator of apical constriction during neurulation.

Here, we focus on the mechanisms by which FGFs control apical constriction and rosette assembly.

We show that apical constriction in the LL primordium requires the activity of non-muscle myosin.

To validate the model, apical constriction and cell elongation were inhibited in Xenopus laevis embryos.

Cell elongation changes cuboidal cells into columnar cells, and apical constriction then causes them to adopt apically narrow, wedge-like shapes.

Shroom-induced apical constriction was associated with enrichment of apically localized actin filaments and required the small GTPase Rap1 but not Rho.

Results: We show here that expression of Shroom is sufficient to organize apical constriction in transcriptionally quiescent, naive epithelial cells but not in non-polarized cells.

The results suggest that apical constriction cued the bending of the neural plate by pursing the circumference of the apical surface of the neural cells.