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Endogenous Xenopus shroom was found to be expressed in cells engaged in apicalconstriction.
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Conclusions: These data demonstrate that Shroom is an essential regulator of apicalconstriction during neurulation.
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Here, we focus on the mechanisms by which FGFs control apicalconstriction and rosette assembly.
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We show that apicalconstriction in the LL primordium requires the activity of non-muscle myosin.
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To validate the model, apicalconstriction and cell elongation were inhibited in Xenopus laevis embryos.
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Cell elongation changes cuboidal cells into columnar cells, and apicalconstriction then causes them to adopt apically narrow, wedge-like shapes.
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Shroom-induced apicalconstriction was associated with enrichment of apically localized actin filaments and required the small GTPase Rap1 but not Rho.
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Results: We show here that expression of Shroom is sufficient to organize apicalconstriction in transcriptionally quiescent, naive epithelial cells but not in non-polarized cells.
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The results suggest that apicalconstriction cued the bending of the neural plate by pursing the circumference of the apical surface of the neural cells.