Significats de lambda light en anglès

Myeloma cells were immunohistochemically positive for IgG and kappa and lambda light chains.

Immunoelectrophoresis showed monoclonal IgG protein associated with two monoclonal kappa and lambda light chain components.

With the free kappa and lambda light chains, new markers to diagnose intrathecal synthesis are available.

To investigate the defect further, the production of lambda light chains was amplified by crossing SJL with kappa-knockout mice.

The genetic organization of the kappa and lambda light chain loci permits multiple, successive rearrangement attempts at each allele.

Immunohistochemical stains revealed that a few plasmacytoid cells showed lambda light chain staining, though most were kappa light chain positive.

Most low-grade lymphoma and chronic lymphocytic leukemia (B-CLL) cells express monoclonal immunoglobulins carrying either kappa or lambda light chains.

However, the free lambda light chains in 20 out of the 110 investigated samples were characterized by inconsistent behaviour.

Rearrangements of both immunoglobulin heavy- and light-chain genes were observed in NOP-2 cells, though the cells expressed detectable mRNA only for Ig- lambda light chain.

Sequence analysis revealed that the bovine immunoglobulin lambda light chain locus consisted of four joining-constant gene recombination units spanning approximately 20 kb DNA in length.

The majority (76%) of 77 monoclonal antibodies adequately tested by ELISA or solid phase RIA contained lambda light chains.

In wild type mice, approximately 95% of B cells express kappa light chains and only approximately 5% express lambda light chains.