1
Myeloma cells were immunohistochemically positive for IgG and kappa and lambda light chains.
2
Immunoelectrophoresis showed monoclonal IgG protein associated with two monoclonal kappa and lambda light chain components.
3
With the free kappa and lambda light chains, new markers to diagnose intrathecal synthesis are available.
4
To investigate the defect further, the production of lambda light chains was amplified by crossing SJL with kappa-knockout mice.
5
The genetic organization of the kappa and lambda light chain loci permits multiple, successive rearrangement attempts at each allele.
6
Immunohistochemical stains revealed that a few plasmacytoid cells showed lambda light chain staining, though most were kappa light chain positive.
7
Most low-grade lymphoma and chronic lymphocytic leukemia (B-CLL) cells express monoclonal immunoglobulins carrying either kappa or lambda light chains.
8
However, the free lambda light chains in 20 out of the 110 investigated samples were characterized by inconsistent behaviour.
9
Rearrangements of both immunoglobulin heavy- and light-chain genes were observed in NOP-2 cells, though the cells expressed detectable mRNA only for Ig- lambda light chain.
10
Sequence analysis revealed that the bovine immunoglobulin lambda light chain locus consisted of four joining-constant gene recombination units spanning approximately 20 kb DNA in length.
11
The majority (76%) of 77 monoclonal antibodies adequately tested by ELISA or solid phase RIA contained lambda light chains.
12
In wild type mice, approximately 95% of B cells express kappa light chains and only approximately 5% express lambda light chains.