Significats de leptomeningeal disease en anglès

She had leptomeningeal carcinomatosis, in which cancer cells invade the fluid-filled membrane surrounding the brain.

Central nervous system disease was defined as one or more brain metastases or as leptomeningeal carcinomatosis.

Adequate early diagnosis and treatment of CVST enabled an excellent survival rate for the patient, despite leptomeningeal carcinomatosis.

Patients and methods: We report a case of leptomeningeal carcinomatosis secondary to endometrial carcinoma and 2 complex cervix cancer cases.

Effective treatment with gefitinib was administered, and the patient survived for 10 months after the diagnosis of CVST and leptomeningeal carcinomatosis.

A confirmatory phase 2 clinical trial is ongoing to assess ceritinib activity in patients with ALK-rearranged NSCLC and brain or leptomeningeal metastases.

A final diagnosis of mammary carcinoma with brain metastasis and meningeal carcinomatosis was made.

Prognosis of CNS relapse was worse for patients with meningeal carcinomatosis when compared with brain metastases.

The median survival after diagnosis of carcinomatous meningitis was 77 days.

Approximately 50% of patients with carcinomatous meningitis die from other causes, including systemic disease.

Therefore, large studies to assess the value of CSF tumor marker changes in carcinomatous meningitis are warranted.

Given our findings, CSF tumor marker evaluation may provide a reliable means and surrogate end-points of monitoring response of carcinomatous meningitis to treatment.

Conclusions: Given our findings, CSF tumor marker evaluation may provide a reliable means and surrogate end-points of monitoring response of carcinomatous meningitis to treatment.

Results: An aggressive variant of breast cancer was revealed: meningeal metastasis complicates less than 3.5% of cases of metastatic breast carcinoma.

Following chronic daily headache, neoplastic meningitis was diagnosed in a non-smoking 44-year-old man.

This assumption was confirmed in xenotransplantation models for neoplastic meningitis or solitary cerebral metastasis, where local virus treatment dramatically improved survival.

In addition, we tested an oncolytic PV recombinant for efficacy in xenotransplantation models of neoplastic meningitis and cerebral metastasis secondary to breast cancer.

Neoplastic meningitis (NM) is a relatively frequent metastatic complication of cancer associated with high levels of neurological morbidity and generally poor prognosis.