Corneal epithelial stem cells are thought to be at the limbus.
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Trabeculectomy was performed through a limbus-based incision in nine eyes of nine patients.
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When epithelial defects extended beyond the limbus, they were healed by conjunctival epithelium.
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Fibroblasts that appeared at the wound site exhibited marked CO activity around the limbus.
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In limbus-destroying eye injuries, corneal transplants nearly always fail.
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GR receptor mRNAs were demonstrated in spiral ligament cells, spiral limbus cells, and spiral ganglion cells.
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The proximal structures had greater diameters nasally, whereas the SVP was larger in the inferior limbus.
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Free grafts from the superotemporal limbus of the same eye were used to cover the exposed sclera.
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These results indicate that only limited proliferative capacity of corneal epithelium remains in the absence of limbus.
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This suggests that epithelial cell renewal at the limbus was accelerated in the presence of disturbed reepithelialization.
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Ocular examination revealed sparing of the limbus.
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To the best of our knowledge, no reports exist on allogeneic corneoscleral limbus tissue transplantation for treatment of these.
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Depth of the anterior chamber at the temporal limbus was graded as a percentage fraction of peripheral corneal thickness.
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Conclusions: Taken together these results, explain in part the immunosuppressive features of this cell population obtained from the human limbus.
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The stem cells are produced by the limbus, an area surrounding the cornea, and eventually differentiate and drift where needed.
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The isolated cells transdifferentiate into corneal epithelial-like cells in conditioned medium containing corneal limbus soluble factors, including their specific marker, keratin12.