Significats de mdr gene en anglès

The mammalian mdr gene family comprises a small number of closely related genes.

Expression levels of each mdr gene are dramatically different in various mouse tissues.

We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse.

In this report, we characterize a second member of the mdr gene family which we designated mdr2.

Alternatively, some groups are investigating transfecting the mdr gene into bone marrow cells to reduce the sensitivity of these cells to cytotoxic agents.

Each of the mdr genes has a specific RNA transcript pattern.

Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for acute leukemia patients.

Recent studies have suggested the potential involvement of genes in the MDR gene family in resistance to quinoline-containing compounds in P. falciparum.

Multidrug resistance in mammalian tumor cells is associated with the overexpression of mdr genes encoding P-glycoproteins, which function as drug efflux pumps.

Collectively, these results indicate that de-differentiated cells up-regulate MDR genes via PERK-Nrf2 signaling and suggest that targeting this pathway could sensitize drug-resistant cells to chemotherapy.