Significats de mediate induction en anglès

The M2 promoter also contains sites which mediate induction of transcription in neural cells by neurally active cytokines.

Thus, the p65 subunit of NF-kappa B is activated in GMCs exposed to cytokine and can mediate induction of gene expression.

A binding assay was performed to determine whether estrogen interferes with HIF-1- mediated induction of VEGF.

The data presented here suggest a role for GBP-i in cytokine- mediated induction of viral and cellular genes.

We hypothesized that the small, cytoplasmic domain of HFE might be necessary for HFE- mediated induction of hepcidin.

The results indicated that the NF-kappaB binding site is essential but not sufficient for TNF- or IL-1- mediated induction.

Stress- mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in experimental models.

Some viruses employ strategies to counteract inflammasome- mediated induction of pro-inflammatory cytokines, but their in vivo relevance is less well understood.

For example, inhibition of the NF-kappaB mediated induction of iNOS in epithelial cells could block important anti-apoptotic and anti-microbial survival mechanisms.

Moreover, p53- mediated induction of Notch1 expression was associated with stimulation of the activity of Notch-responsive reporters.

A growing number of studies document EGCG- mediated induction of apoptotic pathways and inhibition of pro-survival factors when combined with chemotherapy or radiation.

Previously, we demonstrated that a Sp1-based promoter is essential for constitutive transcription and a NF-kappaB-based intronic enhancer is responsible for cytokine- mediated induction.

We hypothesize that uPA- mediated induction of TF occurs in lung ECs to promote increased fibrin deposition in the airways during acute lung injury.

These challenges led to an increased PAD expression and protein citrullination and an ACPA- mediated induction of FLS migration through a mechanism involving phosphoinositide 3-kinase activation.

This block may occur through repression of ISRE- mediated transcription, since NS5A also inhibited the IFN- mediated induction of a reporter gene driven from an ISRE-containing promoter.

We investigated whether retinoids suppressed basal expression of Cox-2 or EGF- mediated induction of Cox-2 in human oral squamous carcinoma cells.