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Meanings of mediate knockdown in anglès
We have no meanings for "mediate knockdown" in our records yet.
Usage of mediate knockdown in anglès
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The neuroprotective effects of plumbagin are abolished by RNA interference- mediatedknockdown of Nrf2 expression.
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Small interfering RNA- mediatedknockdown approaches were used to investigate the molecular determinants of activin-mediated functions.
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Elevated expression of MUC20 in cells promoted migration and invasion, whereas ShRNA- mediatedknockdown inhibited these processes.
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RNA interference- mediatedknockdown of Snail expression suppressed RhoGDI2-induced EMT and invasion, confirming that the effect was Snail-specific.
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Transient silencing of MMP-1 in 21D1 cells via siRNA- mediatedknockdown attenuated cell migration.
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Finally, small-interfering RNA- mediatedknockdown of KLF2 strongly attenuated the ability of mevastatin to increase eNOS and thrombomodulin accumulation in endothelial cells.
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Small interfering RNA- mediatedknockdown of the endogenous Aurora A gene causes a proliferation defect and enhances chemosensitivity in human neuroblastoma cell lines.
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Retroviral expression of the wild-type RMND1 cDNA rescued the biochemical phenotype in subject cells, and siRNA- mediatedknockdown of the protein recapitulated the defect.
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Small interfering RNA- mediatedknockdown of filamin-2 inhibited Rap1-induced redistribution of a2C-ARs to the cell surface and inhibited receptor function.
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Our results showed that siRNA- mediatedknockdown of uPAR and MMP-9, either alone or in combination with radiation modulated a series of events leading to apoptosis.
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In contrast, siRNA- mediatedknockdown of Mekk3 in TC71 Ewing's sarcoma cells had no effect on tumor growth or vessel density.
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Both shRNA- mediatedknockdown of Lmo2 expression and pharmacological inhibition of BCL-2 function in E2A-HLF immortalized cells severely compromised their viability.
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Results: The loss of MPC expression via small interfering RNA- mediatedknockdown or pharmacological inhibition did not affect adipogenesis of 3T3-L1 cells.
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Methods: This study utilized small interfering RNA- mediatedknockdown to assess the requirement of MPC1 for adipogenesis in the 3T3-L1 model system.
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Similar effects were seen in human blood-derived macrophages, in which metformin induced protective genes and M2-like genes, suppressible by si-ATF1- mediatedknockdown.
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Furthermore, TDP-43 overexpression as well as siRNA mediatedknockdown did not affect HIV-1 gene expression and virus production in T cells and macrophages.