Significados de mediate knockdown em inglês

The neuroprotective effects of plumbagin are abolished by RNA interference- mediated knockdown of Nrf2 expression.

Small interfering RNA- mediated knockdown approaches were used to investigate the molecular determinants of activin-mediated functions.

Elevated expression of MUC20 in cells promoted migration and invasion, whereas ShRNA- mediated knockdown inhibited these processes.

RNA interference- mediated knockdown of Snail expression suppressed RhoGDI2-induced EMT and invasion, confirming that the effect was Snail-specific.

Transient silencing of MMP-1 in 21D1 cells via siRNA- mediated knockdown attenuated cell migration.

Finally, small-interfering RNA- mediated knockdown of KLF2 strongly attenuated the ability of mevastatin to increase eNOS and thrombomodulin accumulation in endothelial cells.

Small interfering RNA- mediated knockdown of the endogenous Aurora A gene causes a proliferation defect and enhances chemosensitivity in human neuroblastoma cell lines.

Retroviral expression of the wild-type RMND1 cDNA rescued the biochemical phenotype in subject cells, and siRNA- mediated knockdown of the protein recapitulated the defect.

Small interfering RNA- mediated knockdown of filamin-2 inhibited Rap1-induced redistribution of a2C-ARs to the cell surface and inhibited receptor function.

Our results showed that siRNA- mediated knockdown of uPAR and MMP-9, either alone or in combination with radiation modulated a series of events leading to apoptosis.

In contrast, siRNA- mediated knockdown of Mekk3 in TC71 Ewing's sarcoma cells had no effect on tumor growth or vessel density.

Both shRNA- mediated knockdown of Lmo2 expression and pharmacological inhibition of BCL-2 function in E2A-HLF immortalized cells severely compromised their viability.

Results: The loss of MPC expression via small interfering RNA- mediated knockdown or pharmacological inhibition did not affect adipogenesis of 3T3-L1 cells.

Methods: This study utilized small interfering RNA- mediated knockdown to assess the requirement of MPC1 for adipogenesis in the 3T3-L1 model system.

Similar effects were seen in human blood-derived macrophages, in which metformin induced protective genes and M2-like genes, suppressible by si-ATF1- mediated knockdown.

Furthermore, TDP-43 overexpression as well as siRNA mediated knockdown did not affect HIV-1 gene expression and virus production in T cells and macrophages.