Meanings of metastatic ccrcc in anglès

Conclusions: RH and the development of new lesions may predict survival in metastatic ccRCC.

We demonstrated that MYOF influences cellular proliferation of the metastatic CCRCC cell line by regulating VEGFR2 degradation.

Combined therapies targeting the MYOF and VEGFR2 pathways might be effective against metastatic CCRCC to increase patient survival.

Here we establish a molecular link between HIF stabilization and induction of AXL receptor expression in metastatic ccRCC.

The expression of S100A6 was up-regulated in metastatic ccRCC cells.

Importantly, genetic and therapeutic inactivation of AXL signaling in metastatic ccRCC cells reversed the invasive and metastatic phenotype in vivo.