Significats de neonatal hypothyroidism en anglès

Plasma DHT concentrations in rats subjected to transient neonatal hypothyroidism remained unaltered.

Apparent neonatal hypothyroidism and malformations were not observed in the offspring of either group.

The effect of neonatal hypothyroidism on spermatogenesis was studied in Wistar rats of different age groups.

All other groups of rats subjected to transient neonatal hypothyroidism had consistently low titres of plasma and TIF testosterone.

Conclusion: Continuing antithyroid drug therapy throughout pregnancy prevents postpartum recurrence of Graves' hyperthyroidism without resulting in neonatal hypothyroidism or malformations.

We have previously demonstrated that neonatal and transient neonatal hypothyroidism modulates Leydig, Sertoli, and germ cell numbers, sex steroids and androgen binding protein concentration.

A consistent increase in Leydig cell number was seen in puberal rats subjected to transient neonatal hypothyroidism but decreased in 60 days hypothyroid rats.

Neonatal hypothyroidism was induced by adding 0.02% methimazole in the drinking water from day 9 of gestation, and continually until 14 days old.