Significats de ps-341 en anglès

TUNEL staining indicated that PS-341 treatment sensitizes Tax tumors to DNA fragmentation.

In Tax transgenic mice, PS-341 administered thrice weekly inhibited tumor-associated NF-kappaB activity.

PSI suppressed the growth of AML cell lines more effectively than PS-341.

Both preclinical and clinical studies of novel agents including PS-341 and IMiDs are highlighted.

The tumor tissues treated with PS-341 show no consistent inhibition of NFkappaB activation in vivo.

Annexin V staining indicated that PS-341 response in vivo correlated with sensitivity to apoptosis induced by gamma irradiation.

However, the effect of PS-341 on the growth of tumors in Tax transgenic mice revealed heterogeneity in drug responsiveness.

Radiosensitization by PS-341 was reduced in fish with impaired p53 expression or function but not associated with enhanced expression of select p53 target genes.