1
TUNEL staining indicated that PS-341 treatment sensitizes Tax tumors to DNA fragmentation.
2
In Tax transgenic mice, PS-341 administered thrice weekly inhibited tumor-associated NF-kappaB activity.
3
PSI suppressed the growth of AML cell lines more effectively than PS-341.
4
Both preclinical and clinical studies of novel agents including PS-341 and IMiDs are highlighted.
5
The tumor tissues treated with PS-341 show no consistent inhibition of NFkappaB activation in vivo.
6
Annexin V staining indicated that PS-341 response in vivo correlated with sensitivity to apoptosis induced by gamma irradiation.
7
However, the effect of PS-341 on the growth of tumors in Tax transgenic mice revealed heterogeneity in drug responsiveness.
8
Radiosensitization by PS-341 was reduced in fish with impaired p53 expression or function but not associated with enhanced expression of select p53 target genes.