Significats de regulatory program en anglès

TBI modulates the neuronal excitability resulting in propagation of a neuronal activity-driven gene expression program.

All living creatures change their gene expression program in response to nutrient availability and metabolic demands.

Our study provides molecular-level understanding of a gene expression program in B. abortus that is downstream of σE1.

Notch induces a broad antiapoptotic gene expression program that protects against intrinsic, as well as extrinsic, apoptosis pathways.

Together, these findings indicate that Setd1b serves as maternal effect gene through regulation of the oocyte gene expression program.

However, the heart retains the ability to return to the "fetal" gene program.

Despite the advance, there is no therapy available to reverse the already committed gene program.

In contrast, exposure to arterial laminar flow induces a gene program that confers a largely antiadhesive, antithrombotic effect.

Finally, real-time quantitative PCR revealed an age-dependent recapitulation of the fetal gene program, consistent with a myopathic process.

Finally, we show that OXT acts directly on OXTRs on adipocytes to suppress the white-to-beige transition gene program.

The genetic program for the development of the TMJ remains poorly understood.

It must have been a genetic program, but officially he's an accident.

For Wilson, the genetic program is key to understanding human development on all levels.

The survival and death of lymphoid cells is under the control of a genetic program.

Conclusion: LKB1 and Notch share a common genetic program in the liver, and regulate bile duct morphogenesis.

Mitotic phosphorylation of YAP controls a unique transcriptional program in pancreatic cells.

These results define a transcriptional program that controls diversification of a paramorphic pair.

STAT3 hijacks a subset of ER enhancers to drive a distinct transcriptional program.

HOTAIR overexpression is sufficient to activate the ER transcriptional program even under hormone-deprived conditions.

The cellular response to hypoxia relies on the activation of a specific transcriptional program.

This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision making.

Using a synthetic gene circuit, we show that a transcriptional activator driven by yeast cell-cycle promoters propagates transcriptional oscillations with substantial damping.

Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions.

Accurately predicting noise propagation in gene networks is crucial for understanding signal fidelity in natural networks and designing noise-tolerant gene circuits.

The ability to create designer aTFs will enable applications including dynamic control of cell metabolism, cell biology and synthetic gene circuits.

What is less clear is how these changes interact with trans-acting changes occurring elsewhere in the genetic circuit.

In a normal cell, powerful genetic circuits regulate cell division and cell death.

We found 364 candidate obesity-regulating cis elements and genetic circuits in different cell types.

Cells act like tiny computers, and finally, scientists are figuring out what makes their genetic circuits blink on and off.

This finding leads to the proposal that mathematicians study genetic circuits to find new geometries for which structure theorems may exist.

Further, P-HIPSTer enables discovery of previously unappreciated cellular circuits that act on human-infecting viruses and provides insight into experimentally intractable viruses.

It is envisaged that analysing the cellular 'circuitry' of ongoing molecular networks will become a powerful clinical tool in patient management.