Telomerase is an important mechanism by which cancers escape replicativesenescence.
2
This metabolic signature therefore can be used to predict the onset of replicativesenescence.
3
ECs have a finite number of divisions and enter replicativesenescence after exhaustion of this potential.
4
Cellular replicativesenescence is a permanent growth arrest state that can be triggered by telomere shortening.
5
Once they are critically short, telomeres become dysfunctional and consequently activate a proliferative arrest called replicativesenescence.
6
The relationship between NO production and subculture passages could represent a cutting edge " replicativesenescence index".
7
The proliferative lifespan of normal somatic human cells in culture terminates in a permanent growth-arrested state known as replicativesenescence.
8
Most normal somatic cells enter a state called replicativesenescence after a certain number of divisions, characterized by irreversible growth arrest.
9
In this paper we describe how the numbers of activated T cells can be regulated by two distinct mechanisms, namely apoptosis and replicativesenescence.