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Telomerase is an important mechanism by which cancers escape replicativesenescence.
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This metabolic signature therefore can be used to predict the onset of replicativesenescence.
3
ECs have a finite number of divisions and enter replicativesenescence after exhaustion of this potential.
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Cellular replicativesenescence is a permanent growth arrest state that can be triggered by telomere shortening.
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Once they are critically short, telomeres become dysfunctional and consequently activate a proliferative arrest called replicativesenescence.
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The relationship between NO production and subculture passages could represent a cutting edge " replicativesenescence index".
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The proliferative lifespan of normal somatic human cells in culture terminates in a permanent growth-arrested state known as replicativesenescence.
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Most normal somatic cells enter a state called replicativesenescence after a certain number of divisions, characterized by irreversible growth arrest.
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In this paper we describe how the numbers of activated T cells can be regulated by two distinct mechanisms, namely apoptosis and replicativesenescence.