We undertook this study to examine the biological relevance of Mef2c expression in retinalrod photoreceptors.
2
Background: The retinalrod outer segment is a sensory cilium that is specialized for the conversion of light into an electrical signal.
3
Vertebrate retinalrod outer segments (OS) consist of a stack of disks surrounded by the plasma membrane, where phototransduction takes place.
4
Bovine retinalrod outer segment membranes are enriched in a phosphoinositide-specific phosphodiesterase (phospholipase C) activity strictly modulated by free calcium ion concentration.
5
Specification of retinalrod photoreceptors is determined by several different transcription factors that activate expression of rod-specific genes and repress expression of cone photoreceptor-specific genes.
6
PMID: 23568658 Vertebrate retinalrod outer segments (OS) consist of a stack of disks surrounded by the plasma membrane, where phototransduction takes place.
7
G beta 1 gamma 1 purified from retinalrods was dialyzed into cells via the voltage clamp micro-electrode.