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We undertook this study to examine the biological relevance of Mef2c expression in retinal rod photoreceptors.
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Background: The retinal rod outer segment is a sensory cilium that is specialized for the conversion of light into an electrical signal.
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Vertebrate retinal rod outer segments (OS) consist of a stack of disks surrounded by the plasma membrane, where phototransduction takes place.
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Bovine retinal rod outer segment membranes are enriched in a phosphoinositide-specific phosphodiesterase (phospholipase C) activity strictly modulated by free calcium ion concentration.
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Specification of retinal rod photoreceptors is determined by several different transcription factors that activate expression of rod-specific genes and repress expression of cone photoreceptor-specific genes.
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PMID: 23568658 Vertebrate retinal rod outer segments (OS) consist of a stack of disks surrounded by the plasma membrane, where phototransduction takes place.
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G beta 1 gamma 1 purified from retinal rods was dialyzed into cells via the voltage clamp micro-electrode.