Significats de smad proteins en anglès

Furthermore, classical activin signaling via Smad proteins is necessary for this synergy.

The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins.

This repression is transmitted through TGF-beta signaling and can be regulated by other Smad proteins.

Smad proteins have been identified as major components in the intracellular signaling of TGF-beta family members.

Once in the nucleus Smad proteins interact with other DNA binding proteins to regulate transcription of specific target genes.

Genetic studies of Dpp signaling led to the identification of Smad proteins as central mediators of signal transduction by TGF-beta family members.

Changes in Smad proteins and their complexes upon treatment with TGF-beta were studied in mink lung epithelial (Mv1Lu) cell cultures.

Smad proteins are substrates of the TGF-beta type I receptor and are responsible for transducing receptor signals to target genes in the nucleus.

Transduction of TGF-beta signaling depends on the phosphorylation and activation of Smad proteins by heteromeric complexes of ligand-specific type I and II receptors.

We show that Cyr61 transcription is activated by TGFbeta and that the human Cyr61 promoter contains consensus sequences that bind Smad proteins.