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Significats de sporadic als en anglès
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Ús de sporadic als en anglès
1
We recently identified TDP-43 as the major pathological protein in sporadicALS.
2
Recently, mutations in TARDBP have been linked to familial and sporadicALS.
3
The remaining 90% have no affected family members and are classified as sporadicALS.
4
Results: In total, 373 sporadicALS cases from 35 centers were enrolled.
5
Conclusions: Our data indicate that genetic variation in TARDBP is not a common cause of sporadicALS in North American.
6
Based on these results, there may be a sporadicALS subgroup that progresses slowly and shows no accumulation of phosphorylated TDP-43.
7
Data were obtained from 26 patients with sporadicALS and 26 healthy controls matched for age, education, gender, anxiety, depression and executive function performance.
8
Biochemical analysis of postmortem tissue from sporadicALS and SOD1-negative FALS demonstrated pathological forms of TDP-43 that were absent in cases with SOD1 mutations.