Meanings of sporadic als in English

We recently identified TDP-43 as the major pathological protein in sporadic ALS.

Recently, mutations in TARDBP have been linked to familial and sporadic ALS.

The remaining 90% have no affected family members and are classified as sporadic ALS.

Results: In total, 373 sporadic ALS cases from 35 centers were enrolled.

Conclusions: Our data indicate that genetic variation in TARDBP is not a common cause of sporadic ALS in North American.

Based on these results, there may be a sporadic ALS subgroup that progresses slowly and shows no accumulation of phosphorylated TDP-43.

Data were obtained from 26 patients with sporadic ALS and 26 healthy controls matched for age, education, gender, anxiety, depression and executive function performance.

Biochemical analysis of postmortem tissue from sporadic ALS and SOD1-negative FALS demonstrated pathological forms of TDP-43 that were absent in cases with SOD1 mutations.