We also highlight challenges for understanding thoughtdisorder within an RDoC framework.
2
Moreover, thoughtdisorder is dynamic over time and context within individuals.
3
These processes are implicated in hallucinations, delusions, and thoughtdisorder.
4
As a result, an increasing incidence of thoughtdisorder was detected in relatives of schizophrenics.
5
Frontotemporal activations during language processing tasks were predictive of thoughtdisorder and auditory illusory experiences.
6
Several authors have investigated the presence of thoughtdisorder in psychiatric patients using different reliable methods.
7
In line with previous research, basic symptoms correlated with thoughtdisorder but not with positive symptoms.
8
No individuals with psychotic symptoms had a formal thoughtdisorder, incoherence of speech, or flat affect.
9
Results: Presence of thoughtdisorder, any delusions and elevated mood significantly predicted transition to a psychotic disorder.
10
In this commentary, we discuss ways in which thoughtdisorder can be understood within the RDoC framework.
11
Results were not moderated by sociodemographic background variables, psychomotor slowing and psychopathological symptoms other than thoughtdisorder.
12
However, when the effects of neuroleptic-induced disturbances were controlled for, thoughtdisorder also insignificantly correlated with basic symptoms.
13
Within the schizophrenic group, departure from the normal left greater than right pattern was highly correlated with thoughtdisorder.
14
Conclusions: In line with Spitzer and Maher it is inferred that disinhibited semantic networks underlie formal thoughtdisorder in schizophrenia.
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In sum, RDoC is a useful framework to integrate multidisciplinary research efforts aimed at operationalizing, understanding, and ameliorating thoughtdisorder.
16
There is now considerable evidence supporting the separation of schizophrenic symptoms into three domains: hallucinations and delusions, thoughtdisorder, and deficit symptoms.