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We also highlight challenges for understanding thoughtdisorder within an RDoC framework.
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Moreover, thoughtdisorder is dynamic over time and context within individuals.
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These processes are implicated in hallucinations, delusions, and thoughtdisorder.
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As a result, an increasing incidence of thoughtdisorder was detected in relatives of schizophrenics.
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Frontotemporal activations during language processing tasks were predictive of thoughtdisorder and auditory illusory experiences.
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Several authors have investigated the presence of thoughtdisorder in psychiatric patients using different reliable methods.
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In line with previous research, basic symptoms correlated with thoughtdisorder but not with positive symptoms.
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No individuals with psychotic symptoms had a formal thoughtdisorder, incoherence of speech, or flat affect.
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Results: Presence of thoughtdisorder, any delusions and elevated mood significantly predicted transition to a psychotic disorder.
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In this commentary, we discuss ways in which thoughtdisorder can be understood within the RDoC framework.
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Results were not moderated by sociodemographic background variables, psychomotor slowing and psychopathological symptoms other than thoughtdisorder.
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However, when the effects of neuroleptic-induced disturbances were controlled for, thoughtdisorder also insignificantly correlated with basic symptoms.
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Within the schizophrenic group, departure from the normal left greater than right pattern was highly correlated with thoughtdisorder.
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Conclusions: In line with Spitzer and Maher it is inferred that disinhibited semantic networks underlie formal thoughtdisorder in schizophrenia.
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In sum, RDoC is a useful framework to integrate multidisciplinary research efforts aimed at operationalizing, understanding, and ameliorating thoughtdisorder.
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There is now considerable evidence supporting the separation of schizophrenic symptoms into three domains: hallucinations and delusions, thoughtdisorder, and deficit symptoms.