Significats de unbound drug en anglès

The percentage of unbound drug was slightly higher in both moderately impaired cohorts.

The pharmacodynamic relationship between unbound drug concentration and QT prolongation was fit by a simple linear model.

Arthritic rats exhibited lower plasma and ISF albumin concentrations and reduced clearances of unbound drug to explain pharmacokinetic profiles.

The net effect of chronic inflammation was an elevation of the C max and area under the plasma concentration-time curve (AUC) of unbound drug.

A trend was observed toward more severe hematologic toxicity with the 3-hour schedule (P =.053), consistent with increased exposure to unbound drug.

Unbound drug is the pharmacodynamically relevant concentration.