Type of cell found in pancreatic islets.
1 However, SFRP4 does not control glucose homeostasis and β-cell mass in mice.
2 The islet β-cell is unusual in that glucose lacks an extracellular receptor.
3 This effect was not associated with enhanced β-cell proliferation or mass.
4 Type 2 diabetes incidence increases with age, while β-cell replication declines.
5 This was paralleled by an increase in β-cell proliferation and mass.
6 Insulin sensitivity and β-cell function were examined by homeostasis model assessment.
7 Of these, 16 had not previously been implicated in the regulation of β-cell mass.
8 Monogenic diabetes is caused by mutations that reduce β-cell function.
9 CAG repeat length did not show any significant correlation with IR or β-cell function.
10 In this study, we show how this coupling can produce oscillations in β-cell activity.
11 Here we show that palmitate-induced β-cell apoptosis is mediated by the intrinsic mitochondrial pathway.
12 Thus, MKP-1 is a possible target for anti-inflammatory therapeutic intervention with preservation of β-cell function.
13 Hence, factors controlling functional β-cell compensation are potentially important targets for the treatment of T2D.
14 Glycemia and β-cell function were assessed 1 week later at the peak of viral expression.
15 These data indicate that short-term HFD feeding enhances β-cell proliferation before insulin resistance becomes apparent.
16 Ex-4 nearly normalized both human β-cell survival and rodent β-cell replication when co-administered with tacrolimus.
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