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An accelerated rate of biologicalaging could contribute to this increased risk.
2
Problem: Epigenetic age indices are markers of biologicalaging determined from DNA methylation patterns.
3
A widely used marker of biologicalaging is telomere length.
4
This study assessed the contribution of genetic and nongenetic factors to biologicalaging in American Caucasians.
5
As the biologicalaging process demonstrates gender-specific characteristics, the analyses were performed separately in males and female.
6
These interventions may, however, work through different pathophysiological mechanisms and could differ in their impact on biologicalaging and somatic health.
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Objective: Psychological factors such as the stress of caregiving are emerging as predictors of telomere length, an index of biologicalaging.
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A common mechanism underlying premature declines in health may be accelerated biologicalaging, as reflected by leukocyte telomere length (LTL).
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Background: Depressive and anxiety disorders have shown to be associated to premature or advanced biologicalaging and consequently to adversely impact somatic health.
10
During the course of biologicalaging, there is a gradual accumulation of damaged proteins and a concomitant functional decline in the protein degradation system.
11
Depression and depressive symptoms are associated with a range of morbidities and mortality, but the extent to which they predict biologicalaging is unclear.
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It has been hypothesized that one way in which lower socioeconomic status (SES) affects health is by increasing the rate of biologicalaging.
13
Thus, CR reduces the platelet-derived growth factor-associated signaling cascade, contributing to the postponement of biologicalaging and preservation of a more youthful aortic wall phenotype.
14
Accordingly, we sought to develop a metabolomic signature of biologicalaging that could predict changes in physiological function with the convenience of a blood sample.
15
This study assessed the association between abuse exposure and shortening of telomere length (TL), a promising molecular marker for biologicalaging, in older victims.
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Biologicalaging is associated with physiological deteriorations, which are partly due to changes in the hormonal profile.