Constitutive NF-kB is often found in some types of cancers, contributing to oncogenesis and tumor progression.

This knowledge is key to develop strategies for prevention and treatment of constitutive NF-kB-driven inflammatory diseases and cancers.

Inhibition of constitutive NF-kappaB activation by expression of IkappaBalpha super-repressor reduced proliferation of the basal-like subtype cell lines.

In mice, deficiency of miR-146a results in hematolymphoid cancer at advanced ages as a consequence of constitutive NF-kB activity.

We show in this manuscript that for melanoma there is a strong relationship between expression of the LTbeta-R and constitutive NF-kappaB transcriptional activity.

Aberrant and constitutive NF-kB activation are frequently reported in numerous tumor types, making its inhibition an attractive target for the treatment of certain cancers.

Experimental introduction of CARD11 coiled-coil domain mutants into lymphoma cell lines resulted in constitutive NF-kappaB activation and enhanced NF-kappaB activity upon antigen receptor stimulation.

However, neither the subtypes of breast cancer cells with constitutive NF-kappaB activation nor the molecular mechanisms leading to its constitutive activation have been clearly defined.

BAY 11-7082 (3.5 microM) inhibited constitutive NF-kappaB activity in the three cell lines whereas the anticancer agents did not.

Taken together, these data suggest that suppression of constitutive NF-kappaB activity by BAY 11-7082 may be a useful treatment for MDR leukemias.

These findings demonstrate the physiological relevance of the NF-kappaB2 p100 precursor protein in limiting the potentially detrimental effects of constitutive NF-kappaB2 signaling in lymphocytes.

The identification of a FOXP3-miR-146-NF-kB axis provides an underlying mechanism for disruption of miR-146 family member expression and constitutive NF-kB activation in breast cancer cells.