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The resulting cyclicpeptides are cell permeable and have improved proteolytic stability.
2
Peptide thioesters serve as fundamental building blocks for the synthesis of proteins and cyclicpeptides.
3
Measurements made in the presence of verapamil showed that the cyclicpeptides experienced a ca.
4
However, the MSDIN gene family encoding for these cyclicpeptides in A. fuligineoides has not been systematically studied.
5
However, their applications against intracellular targets have been limited, because cyclicpeptides are generally impermeable to the cell membrane.
6
To improve the biological properties, 10 cyclicpeptides (cPs) were designed from the lead peptides and synthesized.
7
The Compstatin family of cyclicpeptides blocks complement activation at the C3 cleavage step, and is under investigation for treatment of complement-mediated diseases.
8
Alternatively, cyclicpeptides were prepared with stable polyethylene glycol bridges across internal lysine residues of modified antigenic peptides such as KQPFPEKELPY and LQLQPFPQPEKPYPQPEKPY.
9
We report on the design and evaluation of novel cyclicpeptides targeting the N-terminal domain of the protein tyrosine phosphatase YopH from Yersinia.
10
Fusion of cyclicpeptides with a cyclic cell-penetrating peptide produces bicyclic peptides that are cell-permeable and retain the ability to recognize specific intracellular targets.
11
The effect of cyclization as well as the length of the spacer in the cyclicpeptides on DQ2 binding and T cell recognition was analyzed.
12
These cell-permeable cyclicpeptides inhibit Ras signaling by binding to Ras-GTP and blocking its interaction with downstream proteins and they induce apoptosis of cancer cells.
13
Herein we present a method for the combinatorial synthesis and screening of large one-bead-one-compound (OBOC) libraries of cyclicpeptides against biological targets such as proteins.
14
Cyclicpeptides have great potential as therapeutic agents and research tools.
15
Cyclicpeptides have been a rich source of biologically active molecules.
16
Cyclicpeptides (CPs) are an exciting class of molecules with a variety of applications.