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The functional effects of novel DDR2 mutants were confirmed by in vitro assays.
2
Results: We identified novel somatic mutations of DDR2 in two of the 100 SCC samples studied.
3
DDR2 mutations on exons 6, 15, 16, and 18 were analyzed by Sanger sequencing of formalin-fixed, paraffin-embedded tissue samples.
4
In addition, we showed that each of the novel DDR2 mutations were located in a kinase domain and induced an increase in cell proliferation rate.
5
Studying the DDR2 mutations in patients with SCC of the lung would advance our understanding and guide the development of therapeutic strategies against lung cancer.
6
Furthermore we found potentially targetable DDR2 mutations at a frequency of 3% in both adenocarcinomas and squamous cell carcinomas.
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It's also got 512 MB of DDR2 RAM and an integrated Adreno 220 graphics processing unit to render 1080p high-definition video.
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If you need more than the standard 64MB of DDR2-SDRAM memory, a side panel opens for easy access to the upgrade slot.
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The expression of the mutant DDR2 induced activation of DDR2 by the collagen ligand and caused enhanced cell growth and tumor progression.
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Conclusion: Our results suggest that a mutation in DDR2 occurs naturally with a frequency of about 2% in Korean lung SCC patients.