1
HSCT resulted in complete immunological correction, even though mixed donor chimerism occurred.
2
It induces rapid complete donor chimerism without the need for donor lymphocyte infusion.
3
Results: DLI resulted in complete donor chimerism within 2 months of the second infusion.
4
Overall, two of three patients are alive and display 100% donor chimerism.
5
Complete donor chimerism appears necessary to achieve a long-term cure.
6
Overall clinical response correlated with the degree of donor chimerism.
7
Transient or partial donor chimerism can be sufficient to correct the hematological manifestations of osteopetrosis.
8
All patients have normal counts with complete donor chimerism.
9
Stable donor chimerism was achieved in 91% of patients.
10
Complete donor chimerism was demonstrated by cytogenetic and molecular methods up to day +385 post-transplant.
11
Five of 10 patients survive; three with full or partial donor chimerism and two with autologous hematological recovery.
12
In the two patients with less than 95% donor chimerism, the HIV latent reservoir remained stable.
13
Finally, the patient achieved complete donor chimerism and a decline in HHV-6 DNA copy number in whole blood.
14
The patient is currently more than 1 year after transplant with complete donor chimerism and restoration of normal thrombopoiesis.
15
Conclusion: The results suggest that this novel regimen containing 2-CdA is well tolerated and induces early complete donor chimerism.
16
He finally achieved complete remission with full whole blood and T-cell donor chimerism after DLI preceded by lymphodepletion chemotherapy.
