Significados de donor chimerism en inglés

HSCT resulted in complete immunological correction, even though mixed donor chimerism occurred.

It induces rapid complete donor chimerism without the need for donor lymphocyte infusion.

Results: DLI resulted in complete donor chimerism within 2 months of the second infusion.

Overall, two of three patients are alive and display 100% donor chimerism.

Complete donor chimerism appears necessary to achieve a long-term cure.

Overall clinical response correlated with the degree of donor chimerism.

Transient or partial donor chimerism can be sufficient to correct the hematological manifestations of osteopetrosis.

All patients have normal counts with complete donor chimerism.

Stable donor chimerism was achieved in 91% of patients.

Complete donor chimerism was demonstrated by cytogenetic and molecular methods up to day +385 post-transplant.

Five of 10 patients survive; three with full or partial donor chimerism and two with autologous hematological recovery.

In the two patients with less than 95% donor chimerism, the HIV latent reservoir remained stable.

Finally, the patient achieved complete donor chimerism and a decline in HHV-6 DNA copy number in whole blood.

The patient is currently more than 1 year after transplant with complete donor chimerism and restoration of normal thrombopoiesis.

Conclusion: The results suggest that this novel regimen containing 2-CdA is well tolerated and induces early complete donor chimerism.

He finally achieved complete remission with full whole blood and T-cell donor chimerism after DLI preceded by lymphodepletion chemotherapy.