1
Main methods: The formalin test was used to assess the nociceptive activity.
2
The antinociceptive effect of compound 1 was determined using the formalin test.
3
The formalin test was used to assess the nociceptive activity.
4
Local administration of meloxicam produced a dose-dependent antinociception in the second phase of the formalin test.
5
Local administration of diclofenac produced a significant antinociception in both phases of the formalin test in female Wistar rats.
6
The antinociceptive activity of an inhibitor of phosphodiesterase 5, alone or combined with diclofenac, was assessed in the formalin test.
7
The purpose of this study was to assess the possible synergistic interaction between ketorolac and B-vitamins in the rat formalin test.
8
Estradiol significantly decreased nociceptive responses in OVX rats with effects during both the first and the second phase of the formalin test.
9
B. garcibarrigae presented significant effect on the early phase of the formalin test, pointing to an antinociceptive mechanism distinct from traditional anti-inflammatory medicines.
10
Experiment 2 showed a similar shift from antinociception to nociception on the formalin test in mice immediately after removing them from the EPM.
11
The present work assessed the possible participation of K+ channels in the peripheral antinociceptive action of metamizol in the 1% formalin test.
12
The present study assessed the possible pronociceptive role of peripheral and spinal 5-HT(6) receptors in the formalin test.
13
The effects of individual and fixed-ratio combinations of locally (subcutaneous) and systemically (intraperitoneal) dosed tramadol were evaluated using the formalin test in rats.
14
The involvement of the nitric oxide-cyclic GMP pathway in the antinociceptive action of the cyclooxygenase-2 preferential inhibitor meloxicam was assessed in the rat formalin test.
15
Data also suggests that mangiferin activates the NO-cyclic GMP-ATP-sensitive K(+) channels pathway in order to produce its local peripheral antinociceptive effect in the formalin test.
16
Our results suggest that 5-HT(6) receptors play a pronociceptive role in peripheral as well as spinal sites in the rat formalin test.
