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Conclusion: Attention to G6PD status is required for safe prescription of tafenoquine.
2
The effect of G6PD deficiency on risk of pneumococcal disease is undefined.
3
A commercial kit was used for the quantitative measurement of G6PD activity.
4
Quantitative diagnostic tests for G6PD deficiency are complex and require sophisticated laboratories.
5
Conclusion: Access to POC testing for G6PD deficiency in Ghana was poor.
1
Half of the patients co-inherited a-thalassaemia and about one-third had glucose-6-phosphate dehydrogenase deficiency.
2
Some disorders such as hemoglobinopathy, glucose-6-phosphate dehydrogenase deficiency, autosomal recessive syndromes, and several metabolic disorders have a presence throughout the Middle East.
3
Susceptibility to annexin binding is enhanced in several genetic disorders affecting erythrocyte function, such as thalassaemia, sickle-cell disease and glucose-6-phosphate dehydrogenase deficiency.
4
Red-cell membranes from patients with glucose-6-phosphate dehydrogenase deficiency were studied with polyacrylamide gel electrophoresis and gel filtration chromatography in sodium dodecyl sulfate.
Usage of g6pd deficiency in English
1
The effect of G6PDdeficiency on risk of pneumococcal disease is undefined.
2
Quantitative diagnostic tests for G6PDdeficiency are complex and require sophisticated laboratories.
3
Conclusion: Access to POC testing for G6PDdeficiency in Ghana was poor.
4
Erythrocyte G6PDdeficiency is the most common worldwide enzymopathy.
5
Testing for G6PDdeficiency is mandatory before tafenoquine prescription.
6
We evaluated the geographical accessibility to POC testing for G6PDdeficiency in Ghana, a malaria-endemic country.
7
Rapid diagnostic tests capable of diagnosing G6PDdeficiency are now available, but these are not used widely.
8
We hypothesized that G6PDdeficiency increases pneumococcal disease risk and that this effect is dependent upon malaria.
9
Conclusions: Our data demonstrate that G6PDdeficiency increases risk of pneumococcal bacteremia in a manner dependent on malaria.
10
We also obtained the geolocated data of all public hospitals providing G6PDdeficiency testing services in the region.
11
For this reason it is imperative to identify individuals with G6PDdeficiency prior to administering these anti-malarial drugs.
12
To assess the overall effect of G6PDdeficiency trait, deficiency alleles found across all three loci were pooled.
13
Qualitative G6PD tests are sufficient for diagnosing G6PDdeficiency in males.
14
At the population level, the impact of G6PDdeficiency on invasive pneumococcal disease risk in malaria-endemic regions is substantial.
15
These observations may help to explain the discrepancy in some published association studies involving G6PDdeficiency and uncomplicated malaria.
16
Therefore, patients with severe forms of G6PDdeficiency may present impaired NADPH oxidase activity and become susceptible to recurrent infections.