A lipoprotein that transports cholesterol in the blood; composed of a high proportion of protein and relatively little cholesterol; high levels are thought to be associated with decreased risk of coronary heart disease and atherosclerosis.
The structural basis of HDL formation and assembly, however, is poorly understood.
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Summary: The quality of HDL may be more important than HDL-cholesterol levels.
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These effects may be involved in the mechanism of HDL's anti-atherosclerotic action.
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However, the mean concentration of plasma HDL-C remained stable and very high.
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Purpose of review: To determine the potential clinical utility of high-densitylipoprotein-mimetic peptides.
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Abnormal erythrocyte morphology was observed in hypercholesterolemic mice lacking the high-densitylipoprotein receptor SR-BI.
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Adiponectin concentration correlated positively with high-densitylipoprotein cholesterol concentration and negatively with triglyceride concentration.
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Preschool BMI was inversely associated with high-densitylipoprotein levels from the age of 3 years.
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The levels of high-densitylipoprotein cholesterol and apolipoproteins were not affected by boiled or filtered coffee.
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Triacylglycerol, high-densitylipoprotein, and total cholesterol serum levels increased with diet containing coconut oil and cholesterol.
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In multivariate analysis higher TGs levels, but not low high-densitylipoprotein, were associated with the primary endpoint.
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Finally, in transplant patients, we did not find any association between carotid lesions and high-densitylipoprotein subfractions.
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These associations remained significant and independent in multiple regression analysis including age, gender, smoking, and high-densitylipoprotein cholesterol.
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The addition of pioglitazone significantly improved the insulin sensitivity and increased the high-densitylipoprotein cholesterol after 3 months.
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The reference intervals were comparable among male and female participants, with the exception of triglyceride in high-densitylipoprotein.
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No such cutoff points were found for high-densitylipoprotein cholesterol, triglycerides, blood pressure and fasting plasma glucose levels.
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The increase in high-densitylipoprotein cholesterol was greater than that observed in patients with hypercholesterolemia, and appears dose dependent.
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Higher than average values of high-densitylipoprotein cholesterol (HDL-cholesterol) have been observed in people of Japanese ethnicity.
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The model is applied to simulations of discoidal high-densitylipoprotein particles involving water, lipids, and two primarily helical proteins.
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Mean triglycerides were significantly higher and high-densitylipoprotein cholesterol lower in both HIV-positive groups relative to the HIV-negative group.