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Anosmia has been noticed in leukoderma and allied disturbances of pigmentation.
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Figure 293 represents a family of three children, all the subjects of leukoderma.
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Ogle mentions a negro boy in Kentucky whose sense of smell decreased as the leukoderma extended.
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Wood calls attention to the wave-like course of leukoderma, receding on one side, increasing on the other.
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It has been ascribed to syphilis; but syphilitic leukoderma is generally the result of cicatrices following syphilitic ulceration.
1
Hypomelanosis of Ito is characterized by swirly hypopigmentation or depigmentation of the skin with or without other malformations.
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Results: Most patients developed onset of skinhypopigmentation within the first month of treatment and all of the patients experienced additional drug toxicity.
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Methods: In this case series, the authors describe unique clinical findings of skinhypopigmentation in six patients with CML who were treated with imatinib mesylate.
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Conclusion: Skinhypopigmentation is a benign side effect from imatinib mesylate treatment that appears to be reversible upon discontinuation or dose reduction.