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Systems analysis identified the exocyst complex as a key networkhub, rich in genetic interactions with endocytic and exocytic components.
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We found that the networkhub gene Bcat1 and seven other co-regulated MMnet genes out of 13, regulate bone function.
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As an interface, the anterior insula (AI) has recently been shown to be a networkhub, which initiates dynamic switching between these intrinsic networks.
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Conclusions: Interestingly, we find that lncRNA networkhubs tend to be significantly enriched in evolutionary conserved lncRNAs and enhancer-like functions.
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The transcription factors also formed networkhubs with genes from other functional categories, thus allowing regulation of one functional pathway through manipulation of another.
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Results: Compared to controls, patients with schizophrenia and the high risk subjects showed significantly weakened networkhubs in left inferior frontal and right fusiform gyri.
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This work has highlighted the general importance of networkhubs as hotspots for concentration of cortical grey-matter deficits in schizophrenia, Alzheimer's disease and other disorders.