1
In contrast, Pten deletion in mouse organoids does not lead to folding.
2
We characterized the role of ATP7B in mouse intestinal organoids and tissues.
3
This occurred preferentially in non-malignant HCEC, which was corroborated in intestinal organoids.
4
There have been no reports on the use of organoids for gastric function.
5
For example, transcripts of taste receptors appear only or predominantly in late-stage organoids.
1
The organoid model helps identify functional elements that may drive disease onset.
2
Thus, our organoid models reveal human oligodendrogenesis with ventral and dorsal origins.
3
Both these characteristics might lead to major differences in tumor organoid's response to therapy.
4
Finally, we provide evidence supporting the feasibility of organoid studies of human prostate tissue.
5
The organoid cultures contained also some myofibroblasts with potential to promote intestinal stem cell survival.
6
Lineage-tracing demonstrates that luminal cells are favoured for organoid formation and generate basal cells in culture.
7
Mechanism underlying these phenomena and their diversity among vertebrates can be studied in 3D organoid cultures.
8
Treatment with a broad-spectrum kinase inhibitor dasatinib blocked protein aggregate accumulation and restored in vitro organoid formation.
9
We further discuss perspectives on overcoming limitations of current organoid systems for their future use in ZIKV research.
10
The universal methods described can be employed regardless of the type of pluripotent stem cell used and 3-D organoid generated.
11
The advent of the gastric organoid culture system has provided a new model to emulate native epithelial tissue in vitro.
12
PDX-derived organoid cells were evaluated for the presence of MYB-mediated fusion genes and proceeded for in vitro drug sensitivity assay.
13
In an organoid model of IBD, the new agonist increases expression of LRH-1-controlled steroidogenic genes and promotes anti-inflammatory gene expression changes.
14
In this study, we employed a three-dimensional organoid model of human pancreatic cancer to characterize the molecular alterations critical for invasion.
15
Syringocystadenoma papilliferum is a rare benign adnexal tumor that most frequently arises from an organoid nevus on the head and neck.
16
Here, we used homogeneous human bud tip organoid cultures and identified SMAD signaling as a key regulator of the bud tip-to-airway transition.