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pancreas 1
The expression pattern and sequence information indicate that some of the genes could govern pancreas development.
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In addition, the molecular mechanisms by which loss of beta-catenin affects pancreas development are not well understood.
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We have combined suppressive subtractive hybridization with in situ hybridization to identify genes expressed at early stages of pancreas development.
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Many of the β-cell enriched miRNAs have multiple functions and regulate pancreas development as well as insulin biosynthesis and exocytosis.
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During pancreas development, both the exocrine and endocrine lineages differentiate from a common pool of progenitor cells with similarities to mature pancreatic duct cells.
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Here, we will focus on the role of Hh signaling in pancreas development and pancreatic diseases, including diabetes mellitus, chronic pancreatitis and pancreatic cancer.
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Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes.