Process whose specific outcome is the progression of the pancreas (an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes) over time, from its formation to the mature structure.
The expression pattern and sequence information indicate that some of the genes could govern pancreasdevelopment.
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In addition, the molecular mechanisms by which loss of beta-catenin affects pancreasdevelopment are not well understood.
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We have combined suppressive subtractive hybridization with in situ hybridization to identify genes expressed at early stages of pancreasdevelopment.
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Many of the β-cell enriched miRNAs have multiple functions and regulate pancreasdevelopment as well as insulin biosynthesis and exocytosis.
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During pancreasdevelopment, both the exocrine and endocrine lineages differentiate from a common pool of progenitor cells with similarities to mature pancreatic duct cells.
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Here, we will focus on the role of Hh signaling in pancreasdevelopment and pancreatic diseases, including diabetes mellitus, chronic pancreatitis and pancreatic cancer.
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Pancreasdevelopment, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes.