1
Preterm infants exposed to severe placental inflammation have an increased risk of brain injury.
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The determinants of adverse health outcomes among HEU children are poorly understood but may result from chronic placental inflammation (CPI).
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ZIKV inoculation at E10 causes placental inflammation, placental dysfunction and reduces neonatal brain cortical thickness, which is associated with increased activation of microglia.
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Cord blood IL-8, TNF-a and G-CSF may be involved in the process of brain injury in preterm infants with placental inflammation and FIRS.
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Objective: We studied whether magnetic resonance imaging (MRI) could be used to detect placental inflammation before the detection of irreversible tissue damage.
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Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.
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The placental inflammation was confirmed by HCA, and FIRS was defined in fetuses with preterm labor and an elevation of the fetal plasma interleukin-6 concentration.
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The grade 2 and grade 3 of placental inflammation and the inflammation at stage 2 and stage 3 increased the risk of brain injury.
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Placental inflammation was assessed by determination of the levels of inflammatory cytokines.
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Conclusions: Placental inflammation and FIRS are associated with brain injury in preterm infants.
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Results: Placental inflammation was detected by MRI as early as 3 hours after maternal administration of lipopolysaccharide, concomitantly to IL-1β up-regulation.
