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We compared the effect of rhDNase and HS on cationic proinflammatory mediators in CF sputum.
2
In summary, we were unable to show that rhDNase or HS promote airway inflammation in CF.
3
When changes in mediator levels with daily rhDNase were compared with alternate-day rhDNase and HS, no significant differences were detected.
4
The double-blind, 14 day study showed no significant improvement in pulmonary function but some patients may have improved after longer administration of rhDNase.